CD40-TRAF6 and Autophagy-Dependant Anti-Microbial Activity in Macrophages
نویسندگان
چکیده
منابع مشابه
Targeting CD40-Induced TRAF6 Signaling in Macrophages Reduces Atherosclerosis
BACKGROUND Disrupting the costimulatory CD40-CD40L dyad reduces atherosclerosis, but can result in immune suppression. The authors recently identified small molecule inhibitors that block the interaction between CD40 and tumor necrosis factor receptor-associated factor (TRAF) 6 (TRAF-STOPs), while leaving CD40-TRAF2/3/5 interactions intact, thereby preserving CD40-mediated immunity. OBJECTIVE...
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CD40 receptor is a member of the TNF receptor family with a prominent role in the regulation of adaptive immune response. The receptor’s stimulation by specific CD40 ligand (CD40L) results in activation of macrophages, B cells, and dendritic cells. Vascular cells also express CD40, and stimulation by CD40L mediates inflammatory responses in the vascular wall. The 2 major signaling mediators dow...
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ژورنال
عنوان ژورنال: Autophagy
سال: 2007
ISSN: 1554-8627,1554-8635
DOI: 10.4161/auto.3717